Fun fact: they made Joe do this procedure awake, under no sedation or anesthesia (just local anesthesia to the eye) because he was a hard stick. Has anyone else ever done cataract surgery completely awake? Also to answer your questions: Long-term use of immunosuppressants, especially calcineurin inhibitors (like tacrolimus or cyclosporine) and steroids such as prednisone, increases the risk of cataract development. Steroids are the bigger culprit, as they can cause the lens proteins in the eye t